Joint pain affects millions—whether it’s occasional stiffness or chronic arthritis, the impact on daily life can be overwhelming. While prescription medications offer some relief, they often come with side effects. That’s why more people are turning to clinically tested, natural joint supplements for long-term pain management, mobility, and inflammation relief.
In this guide, we’ll uncover the 10 best joint pain relief supplements that combine science-backed ingredients, optimal dosing, and real-world results—so you can move better, feel stronger, and live pain-free.
Some people will turn to options like prescription pain relievers to try and improve pain levels. However, while these have proven benefits, patient care studies also show they can cause side effects. Others prefer more natural ways, like physical therapy or joint health supplements.
Many supplements can provide the same pain relief as prescription medications without posing any risks, giving you the best of both worlds. The only issue is that, as they often contain many unusual ingredients, it can be challenging for the average person to know which joint supplement to use.
That is why we have created the following guide to the best joint pain relief supplements on the market today: to ensure everyone can reduce joint pain and get on with their lives.
FlexAgain is easily the best joint supplement on the market today. It contains only optimal doses of high-quality, scientifically proven, natural ingredients. It is a perfect choice for almost anyone who wants to relieve mild joint aches or treat arthritis or chronic joint pain.
It has 1100 mg of omega-3 fatty acids, 500 mg of curcumin extract, 400 mg of glucosamine sulfate, 250 mg of chondroitin sulfate, 250 mg of ginger and blue galangal extracts, 100 mg of bromelain, 100 mg of resveratrol, 100 mg of boswellic acid, 50 mg of MSM, 70 mcg of vitamin K, and 15 mcg of vitamin D.
The main component of FlexAgain is omega-3 fatty acids, commonly found in fish oil, legumes, nuts, and seaweed. They come in three forms: ALAs (alpha-linolenic acid), EPAs (eicosapentaenoic acid), and DHAs (docosahexaenoic acid).
They are highly effective for improving joint lubrication and the growth of connective tissues and cartilage, relieving pain and inflammation caused by autoimmune and degenerative diseases, such as joint arthritis, and offering many other benefits, like reducing the risk of heart disease.
Taking vitamin D will not directly improve joint health, but it can reduce joint pain if you are vitamin D deficient and prevent you from developing a deficiency. This is because randomized clinical trials show that a vitamin D deficiency can cause joint pain and other adverse health effects.
Vitamin K keeps the joint space healthy in a similar way and also improves the absorption and efficacy of other fat-soluble vitamins, such as vitamin D. The Arthritis Foundation also says that vitamin K can be especially useful for treating joint pain caused by conditions like knee osteoarthritis.
Ginger is a root extract with antioxidant and anti-inflammatory properties that can help control inflammation. Inflammation is one of the top causes of joint swelling and pain and a big reason your symptoms may not improve.
Blue galangal extract is also a root extract that offers anti-inflammatory benefits. It is prevalent in many traditional Asian medicines. It can reduce pain and inflammation and make other medications that contain anti-inflammatory compounds easier to absorb and more effective.
Existing research by the Arthritis Foundation shows that joint pain supplements containing both ingredients are up to 12 times as effective as supplements using either ingredient alone.
Boswellic acid is extracted from Boswellia serrata trees native to India and parts of Pakistan. Resveratrol comes from grape seeds, grapevines, almonds, and some fruits and veggies. Curcumin is a chemical found in turmeric extracted from the roots of the Curcuma longa plant.
All three have potent antioxidant and anti-inflammatory properties that can alleviate joint pain and prevent damage to or loss of connective tissue and cartilage. Curcumin also blocks free radicals, preventing them from causing oxidative stress, damage, and new inflammation.
Chondroitin and glucosamine sulfate supplements are often used together, as studies on integrative medicine show they produce incredible pain-relieving effects when combined. They can help relieve anything from mild joint aches to chronic pain or rheumatoid arthritis and its symptoms.
MSM (methylsulfonylmethane) is a natural compound with a high sulfur content in many green vegetables, such as broccoli. Bromelain is an enzyme almost exclusively extracted from pineapples, and some studies show it can be highly effective in improving digestion.
Both compounds can provide joint pain relief, ease rheumatoid arthritis symptoms, repair cartilage, and restore any joint function that may have been lost due to inflammation or cartilage degradation.
The Arthritis Foundation also states that MSM is especially adequate in joint health supplements that contain chondroitin and glucosamine sulfate, as all three ingredients enhance each other's effectiveness.
While many joint supplements use only one or a few ingredients, FlexAgain utilizes a wide range to boost joint health and functions and relieve joint pain from virtually every angle. We feel it is far superior to all other joint pain supplements today.
Joint Buddy is a leading supplement designed to effectively relieve joint pain by blending high-quality, scientifically supported ingredients. It is tailored to assist anyone experiencing mild joint discomfort or individuals managing arthritis or chronic joint pain. With optimal dosages of proven ingredients, Joint Buddy offers a multifaceted approach to joint health.
It contains 1500 mg of glucosamine sulfate, 150 mg of chondroitin sulfate, 1200 mg of MSM (methylsulfonylmethane), 375 mg of green-lipped sea mussel, 45 mcg of vitamin A, 1.5 mg of vitamin C, 1 mg of vitamin E, 1.5 mg of thiamine, 1.5 mg of riboflavin, 1.5 mg of niacin, 1.5 mg of vitamin B6, 15 mcg of vitamin B12, 0.3 mg of Zinc, 30 mcg of selenium, 0.15 mg of copper, 0.47 mg of manganese, 30 mcg of chromium, 15 mg of L-histidine, 1.5 mg of boron, 37 mg of alfalfa powder, 1.5 mg of yucca, 1.5 mg of devil's claw, and 1.5 mg of cetyl myristoleate.
The primary ingredient, glucosamine sulfate, supports cartilage regeneration, improves joint lubrication, and reduces pain linked with osteoarthritis and other joint issues. It plays a crucial role in maintaining joint structure and comfort by slowing cartilage degradation.
Chondroitin sulfate complements glucosamine to enhance joint support, crucial in maintaining cartilage elasticity and hydration. It is well-regarded for its ability to reduce pain and improve joint function, especially when combined with other joint-supportive nutrients.
MSM (methylsulfonylmethane) provides additional support for joint health through its high sulfur content, essential for collagen synthesis and connective tissue repair. It reduces inflammation, alleviates pain, and promotes recovery from exercise-related and chronic joint disorders.
Vitamins A, C, E, and B-complex and minerals such as Zinc, selenium, and copper offer antioxidant support, enhance immune function, and contribute to overall joint and bone health. These micronutrients help reduce oxidative stress, support tissue repair, and improve the body's response to inflammation.
Alfalfa powder, yucca, and devil's claw are natural plant extracts traditionally used for their anti-inflammatory and pain-relieving properties. These ingredients help to manage symptoms of joint pain and inflammation, making Joint Buddy a holistic solution for joint health.
Cetyl myristoleate is a unique fatty acid known for its joint lubrication properties and ability to support smooth joint movement. It helps protect joints from wear and tear, making it a critical component for long-term joint health maintenance.
Joint Buddy stands out for its comprehensive approach, combining various ingredients to address joint pain and improve overall joint function. Unlike many supplements focusing on one or two key ingredients, Joint Buddy provides a well-rounded formula that tackles joint health from multiple angles, ensuring effective pain relief and support for joint mobility.
Our list is primarily dedicated to joint supplements, but Estrocare is a new menopause supplement. However, as joint pain is a common symptom of menopause and it uses an optimally dosed, clinically proven formula that treats all of the symptoms, it is an ideal choice for menopausal women with painful joints.
Estrocare contains 15 mcg of vitamin D3, 100 mg of DHEA, 700 mcg of vitamin A, 1 mg of vitamin B6, 2.4 mcg of vitamin B12, 6 mg of iron, 25 mg of vitamin C, 8 mg of Zinc, 120 mg of black cohosh, 80 mg of red clover, 300 mg of ginseng extract, 200 mg of 5-htp, 6 million cfu of bifidobacterium animalis, 6 million cfu of lactobacillus gasseri, 200 mcg of chromium, 100 mg of soy isoflavones, 100 mg of calcium citrate, 200 mg of magnesium, 200 mg of 4:1 maca root extract, and 4 mg of Siberian rhubarb extract.
We already saw vitamin D3 in FlexAgain, and it will again prevent or cure any vitamin D deficiencies, keeping the joints healthy and preventing joint pain before it begins.
DHEA is a hormone secreted by the adrenal glands that controls sex hormone production. It can prevent or treat joint pain, depression, sexual dysfunction, and weight gain and improve bone, heart, and immune system health, energy levels, insulin sensitivity, stamina, and physical performance.
Vitamin A keeps the bones, eyes, lungs, skin, and immune system healthy and functional. Women must keep their levels up as they age to help maintain healthy living.
Vitamin B6 and B12 improve the health and functions of the immune system and support the brain. They do this by preventing or treating brain fog, depression, mood swings, and poor mental clarity and energy levels, all of which affect overall health.
Vitamin C also keeps the brain and immune system healthy and functional. Still, it is beneficial to improve skin, bone, and joint health and strength in menopausal women. This is because it stops collagen production from decreasing, which often occurs when you have low oestrogen levels.
Older women are also at a high risk of developing a deficiency in minerals like iron and calcium. This will cause issues like poor skin, nail, and bone health, tiredness, weakness, and head and chest pains, so you must keep your levels up with supplements to prevent these issues from developing.
Chromium helps prevent calcium deficiency by improving the body's absorption ability. It also improves cholesterol and blood sugar levels, insulin sensitivity, mental health, and physical performance.
Taking magnesium will stop you from developing a deficiency in that mineral as well, while also treating menopause symptoms like hot flashes, night sweats, mood swings, sleep issues, anxiety, fatigue, joint pain, cramps, poor sleep quality, and low bone density.
The final mineral in the formula, Zinc, is an anti-inflammatory that can be useful for treating joint pain, weakness, tiredness, anxiety, and a low sex drive and improving eye health, vision, and nervous and immune system health and functions.
Black cohosh is an herbal extract native to eastern North America that alters the brain's production of neurotransmitters and hormones. This can help combat menopausal symptoms like hot flashes and night sweats.
Red clover extract contains isoflavones that reduce hot flashes and night sweats, regulate hormone levels, and keep the body and lungs healthy, especially for asthmatic women. The presence of added soy isoflavones makes these benefits even more prominent.
Ginseng extract comes from the roots of plants in the panax family, and it is known to support healthy hormone and energy levels and cognitive functions and prevent fatigue, hot flashes, mood swings, low libido, sleep problems, joint pain, and vaginal dryness.
Siberian rhubarb extract comes from a European plant known as false rhubarb and can ease joint pain and virtually all other known symptoms of menopause.
Bifidobacterium animalis and Lactobacillus gasseri are a pair of probiotics, a type of healthy bacteria living in your gut. They can help to both prevent or combat vaginal dryness and poor digestion and gut health while being very useful for treating arthritis pain and symptoms.
5-htp (5-hydroxytryptophan) is an amino acid that can improve sleep quality and prevent or treat hot flashes and headaches. The maca root extract has then been shown to provide similar benefits to 5-htp, at the same time as being able to help prevent or combat depression.
Every ingredient is also optimally dosed to provide maximum benefits without causing any side effects. This means that while Estrocare may not have been explicitly created as a joint supplement, it can still be one of the very best joint supplements on the market for women going through menopause.
Osteo Bi-Flex One Per Day is a gluten-free joint supplement designed to improve joint comfort in as little as seven days. It also helps to support immune system health and functions and does not require you to swallow handfuls of pills every day, as the whole formula fits in a single capsule.
The Osteo Bi-Flex One Per Day formula consists of 1,500 mg of glucosamine hydrochloride, 10mcg of vitamin D3, and 100 mg of their patented Joint Shield 5-LOXIN Advanced boswellia serrata resin extract.
Glucosamine hydrochloride is slightly more effective than glucosamine sulfate in combating rheumatoid arthritis and joint pain. It still has the same ability to relieve pain and repair cartilage, but it is slightly more potent and manageable for the body to absorb.
Boswellia serrata extract will help relieve joint pain and inflammation, prevent cartilage and connective tissue degradation, combat free radicals, and reduce cytokine levels, oxidative damage, and stress.
Vitamin D3 will then prevent vitamin D deficiencies and the health issues that come with them, such as inflammation and joint pains.
There are a couple of issues with Osteo Bi-Flex One Per Day that we do have to point out, though. The main problem is that it does not feature either chondroitin or MSM. As both of these have been proven to boost the efficacy of glucosamine significantly, the supplement will be a little harder for the body to utilize.
The dosage of vitamin D3 is also lower than you would ideally like it to be for it to produce the maximum benefits it can. However, given the supplement's price range, this should not be too surprising, as cheaper supplements usually use lower doses to keep the cost down.
That is why, while it certainly will not be for everyone, if you are mainly set on using a supplement that relies heavily on glucosamine but does not cost a fortune or require you to take lots of pills or servings, Osteo Bi-Flex One Per Day can still be one of the best joint supplements for you to try.
FlexAgain Cream is a new supplement from the manufacturers of the best joint supplement on Earth. Designed as a topical cream rather than an ingested supplement, it is ideal for people suffering from joint pain who do not want to put unfamiliar ingredients in their bodies.
The FlexAgain Cream has a formula containing 2% menthol, 2% MSM, 0.25% eucalyptus oil, and capsaicin from chili oil.
MSM will provide the same anti-inflammatory and antioxidant properties that it did previously, enabling it to improve your joint health, combat the symptoms of osteoarthritis, and prevent inflammation and damage to the rest of your body.
Menthol is an extract of the peppermint plant that has proven anti-inflammatory benefits when used as a topical treatment. When applied directly to the afflicted joint, it reduces pain and inflammation while providing a cooling sensation that allows you to continue performing your normal activities.
Capsaicin is a chemical in some chili peppers that can significantly reduce inflammation and relieve joint pain and arthritis symptoms. It is also a bioavailability enhancer, making all the other ingredients present easier to absorb and more effective.
Eucalyptus oil is extracted from the leaves of the eucalyptus plant and has been proven to ease joint pain and inflammation. Studies show that it can provide almost immediate relief from the pain caused by osteoarthritis, rheumatoid arthritis, and sprains.
This formula is particularly impressive because menthol makes eucalyptus oil more effective, while capsaicin notably improves the effects of menthol and MSM. This means it is perfectly balanced to work in synchronicity and produce the most potent effects possible.
While it is admittedly better suited for providing short-term relief than curing your issues, this is true of all topical creams. For best results, it should be combined with an oral supplement. This is where it comes into its own, as it has been optimized to work perfectly with normal FlexAgain.
Today, we rank FlexAgain Cream as the best cream or topical treatment for joint pain.
Vegans often can't use omega-3 supplements because, despite their effectiveness, omega-3 fatty acids often come from fatty fish or fish oil. This can lead to them having to make do with ASU supplements (avocado soy unsaponifiable), which offer similar benefits to omega-3s but are far less effective.
Nordic Naturals Vegan Algae Omega is a far more effective alternative to try if you find yourself in this situation. Each serving contains a reasonable 715 mg of pure omega-3 fatty acids sourced from marine algae oil, high oleic sunflower oil, and rosemary extract.
This allows it to boost joint lubrication and connective tissue growth, reduce harmful C-reactive protein production, and help relieve inflammation and the pain and symptoms of degenerative autoimmune diseases like arthritis. It is also beneficial for treating common physical issues, such as knee pain.
Admittedly, there are some issues with Nordic Naturals Vegan Algae Omega. Not only is the dose of omega-3s present a little low, but the omega-3 sources are all lumped in a single proprietary blend, which means you cannot see how much of each is present or accurately predict the effect it will have.
These factors could make it far less effective than an everyday omega-3 supplement.
That said, as vegan omega-3 supplements are not very common and this one can provide a reasonable level of improvement in people with joint issues, Nordic Naturals Vegan Algae Omega is still among the best options for vegans who are seeking omega-3 supplements but struggling to find one they can use.
Solgar Glucosamine, Hyaluronic Acid, Chondroitin, and MSM is a gluten, GMO, and shellfish-free supplement designed to support healthy joints, a better range of motion, and improved flexibility, all while reasonably priced.
The Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM formula consists of 1500 mg of shellfish-free glucosamine hydrochloride, 1200 mg of chondroitin sulfate, 1500 mg of MSM, and 300 mg of BioCell Collagen II, which contains 180 mg of hydrolyzed collagen type II, 48 mg of chondroitin sulfate, and 30 mg of hyaluronic acid.
MSM, glucosamine, and chondroitin have all been found in many of the other supplements we have examined, and they will again reduce pain, inflammation, and rheumatoid arthritis symptoms, repair damaged cartilage, and restore joint functions in the same ways.
The only difference is that Solgar Glucosamine, Hyaluronic Acid, Chondroitin, and MSM contain glucosamine and chondroitin extracted from sources like fungus or grown in a lab rather than shellfish.
Collagen type II is a protein found naturally in mammals that is the foundation of joints, cartilage, bones, connective tissues, muscles, hair, nails, and skin. It is vital for maintaining many aspects of the human body, and supplementing your intake will also help boost your metabolic rate.
Hyaluronic acid is a polysaccharide that can improve cartilage, connective tissue, joint health, strength, mobility, flexibility, and elasticity. It can also reduce joint pain and stiffness, improve eye and skin health and functions, and reduce healing time, wrinkles, and the signs of aging.
The only issue with Solgar Glucosamine, Hyaluronic Acid, Chondroitin, and MSM is that both hyaluronic acid and collagen type II are present in doses that are far too low for them to be effective.
Many people may also have an issue with collagen seemingly being snuck in, especially as being labeled "shellfish free" could erroneously lead to some people thinking it is suitable for vegetarians.
However, suppose you are not worried about being vegetarian and have a shellfish allergy. In that case, Solgar Glucosamine, Hyaluronic Acid, and Chondroitin, MSM can still be one of the best MSM, glucosamine, and chondroitin supplements for you to try.
Physio Flex Pro is one of the top supplements for treating osteoarthritis, especially knee osteoarthritis, and the chronic pain it can cause. It contains only natural ingredients, yet some studies suggest that the compounds it uses can rival most prescription medications for osteoarthritis sufferers.
Its formula contains 200 mcg of selenium citrate, 500 mg of glucosamine hcl, 300 mg of bromelain from pineapples, 250 mg of ginger root extract with 5% gingerols, 200 mg of turmeric extract with 95% curcuminoids, 100 mg of chondroitin sulfate, 100 mg of MSM, and 10 mg of black pepper fruit extract.
Some of the other joint supplements we have examined contain bromelain, chondroitin sulfate, glucosamine hydrochloride, MSM, ginger, and turmeric extracts. Due to the different dosages present, they will again function in the same ways, albeit to differing degrees.
Between them, they will help ease joint pain and arthritis symptoms, reduce and prevent inflammation, swollen joints, oxidative stress, and damage, promote healthy, functional joints, repair damaged cartilage, and combat free radicals in the same ways that they did before.
The human body naturally produces the trace mineral selenium, which can help reduce inflammation, boost cartilage and synovial fluid production, improve joint lubrication and flexibility, ease joint stiffness, and treat all known arthritis symptoms, especially knee pain caused by osteoarthritis.
The black pepper fruit extract is another anti-inflammatory that can relieve painful joints. It is mainly added to the formula to boost the absorption and efficacy of all other ingredients, and it does this exceptionally well in joint supplements containing turmeric.
Admittedly, Physio Flex Pro is one of the more expensive joint supplements on the market, even though many of its ingredients are in lower dosages than options like FlexAgain, which means it will not promote healthy bones or joints to the same level.
However, if you suffer from osteoarthritis and are not worried about money, Physio Flex Pro can still be one of the best joint supplements for you to try.
Elm & Rye Turmeric is a supplement sold in either gummies or capsules, meaning it is an anti-inflammatory that gives you a choice on how to take it. It contains only one active ingredient, 700 mg of pure turmeric extracts, plus a few ingredients to create the gummy or capsule and stabilize it.
As we saw in FlexAgain, turmeric contains a chemical called curcumin. This potent anti-inflammatory can relieve inflammation and joint pain, prevent joint, cartilage, and connective tissue damage or aid their repair, block free radicals, lower cytokine levels, and reduce oxidative stress and damage.
Many turmeric supplements use only a tiny amount due to their high price. Still, the turmeric used here is impressive and more than enough to deliver the most potent effects it can.
The only issue is that curcumin is hard for the human body to absorb without a bioavailability enhancer, like black pepper or blue galangal extract. As no such compound is present here, you must take an additional supplement to make it work properly, raising the already high cost.
However, if you are set on using only turmeric, do not mind the added cost of buying a secondary supplement, and would like a choice of gummies and capsules, Elm & Rye Turmeric is the best turmeric product for you to try.
Gaia Pro Discomfort Relief is a vegan supplement that supports healthy joints while being dairy, soy, and gluten-free. Unlike most capsules containing a powder, these include a liquid intended to make the supplement extremely fast-acting.
Gaia Pro Discomfort Relief uses what they call the NF-KB Formula, which includes 30 mg of curcumin (from 32 mg of turmeric), 10 mg of black pepper extract, 10 mg of organic ginger root extract, and a 954 mg proprietary blend of turmeric, devils claw root, quercetin, and Boswellia serrata resin extracts.
We have seen curcumin, black pepper extract, ginger root, and Boswellia serrata extract countless times before, albeit usually in larger dosages. They will again reduce pain, inflammation, and swelling, repair damaged cartilage, block free radicals, and prevent oxidative stress and damage to some degree.
Quercetin is a bioflavonoid found in fruits and vegetables like apples and onions. Studies have shown it has anti-inflammatory, antioxidant, and anti-atherogenic effects on human cells. While it has low bioavailability, it can be quite effective when combined with black pepper extract.
Devil's claw root is a type of tuber. Its extract has been shown to relieve pain in people who have musculoskeletal disorders, such as rheumatoid and osteoarthritis. It also suppresses hunger, which can help you lose weight and is beneficial for joint issues.
Admittedly, most of the dosages in Gaia Pro Discomfort Relief are lower than what you will find in the most potent joint supplements so that the results will be less impressive. However, it is rare to see a vegan joint health supplement offering a wide range of ingredients and beneficial effects.
That is why, despite its shortcomings, we still recommend Gaia Pro Discomfort Relief as the best joint supplement for vegans who want to support their joints from every angle.
Natural joint supplements are a fantastic way for people suffering from joint pain to find relief and return to their regular lives without worrying about side effects. There are several great joint supplements on the market, although the best option for most people will be FlexAgain.
Packed with optimal doses of a wide range of clinically proven ingredients, it can help ease joint pain and improve joint health from virtually every angle while not containing fish oil. This makes it an excellent choice for everyone, from people with mild joint pain to chronic arthritis.
If, for any reason, you feel it is not the right option for you, then one of the other options on our list of the best joint supplements surely will be. For everyone else, though, we highly recommend that you try FlexAgain and see how effectively it can benefit your joint health and pain levels for yourself.
