Bills vs Eagles Betting Preview for Week 17 on 12/28/25

The Philadelphia Eagles will play against the Buffalo Bills at Highmark Stadium in Orchard Park, NY. The game is set for Sunday, December 28, 2025, at 4:25 PM. Weather details are not available at this time.

The Eagles have a season record of 10-5-0. They recently won against the Washington Commanders with a score of 29-18. The Bills hold a record of 11-4-0 and recently won against the Cleveland Browns with a score of 23-20. Both teams aim to end the season on a high note.

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Bills vs Eagles at a Glance

• Date: Sunday, December 28, 2025
• Time: 4:25 PM (Afternoon Game)
• Get Tickets: Tickets are available on StubHub
• How to Watch on TV: FOX
• Live Stream: Watch the game on Fubo
• Location: Orchard Park, NY
• Venue: Highmark Stadium

Bills vs Eagles Game Odds

	Total	Bills Moneyline	Eagles Moneyline	Bills Spread	Eagles Spread
BetMGM	45.0 (-110)	-120	+100	-2.5 (-110)	+2.5 (-110)	Bet on this game at BetMGM
FanDuel	43.5 (-105)	-110	-106	-1.5 (-104)	+1.5 (-118)	Bet on this game at FanDuel
Caesars	43.5 (-109)	-120	+101	-1.5 (-107)	+1.5 (-113)	Bet on this game at Caesars

Eagles Preview

The Philadelphia Eagles are set to play the Buffalo Bills in Week 17 of the 2025 season. The Eagles have a record of 10-5 and have shown strength on both offense and defense. Jalen Hurts leads the team as quarterback with 3,114 passing yards and 24 touchdowns this season. Saquon Barkley is a key player with 1,072 rushing yards. In their last game, the Eagles won 29-18 against the Washington Commanders, with Hurts throwing for 185 yards and two touchdowns. With a solid road record of 5-3, the Eagles aim to continue their winning streak at Highmark Stadium.

Eagles Injuries

• Lane Johnson (OT) | Questionable | Foot | Week 17
• Ogbo Okoronkwo (OLB) | Out | Triceps | On injured reserve, will miss at least four games
• Azeez Ojulari (OLB) | Out | Hamstring | On injured reserve, will miss at least four games
• Nakobe Dean (LB) | Questionable | Hamstring | Week 17
• Jalen Carter (DT) | Questionable | Shoulders | Week 17
• Johnny Wilson (WR) | Out | Knee/Ankle | On injured reserve, will miss entire season
• Cameron Latu (TE) | Questionable | Stinger | Week 17
• Ben VanSumeren (FB) | Out | Knee | On injured reserve, will miss remainder of season
• Cameron Williams (OT) | Questionable | Shoulder | 21-day practice window opened
• Andrew Mukuba (S) | Out | Ankle | On injured reserve, will miss at least four games
• Myles Hinton (OT) | Out | Undisclosed | On injured reserve, will miss remainder of season
• Willie Lampkin (C) | Out | Knee | On injured reserve, will miss remainder of season
• Luke Felix-Fualalo (OT) | Out | Undisclosed | On injured reserve

Eagles Stats

The Philadelphia Eagles have shown a balanced performance this season. Jalen Hurts is a standout with 3,114 passing yards, ranking first on the team. Saquon Barkley contributes with 1,072 rushing yards, also leading the team. A.J. Brown and DeVonta Smith are key receivers, with Brown averaging 66.8 receiving yards per game and Smith close behind. The Eagles' defense is strong, highlighted by their second-place rank in opponent scoring last season. They have a solid road record of 5-3, which will be crucial against the Buffalo Bills.

Bet on the Eagles at FanDuel.

Bills Preview

The Buffalo Bills have been performing well this season with an 11-4 record. At home, they have a strong 6-1 record. Their recent games show a winning streak, with victories against the Browns, Patriots, and Bengals. Josh Allen leads the team with impressive stats, including 3,406 passing yards and 25 touchdowns. James Cook is a key player, leading in rushing yards. The Bills aim to maintain their form as they host the Philadelphia Eagles at Highmark Stadium.

Bills Injuries

• Matt Prater (K) | Questionable | Right Quad | Week 17
• Jordan Poyer (S) | Questionable | Hamstring | Week 17
• Darius Slay (CB) | Out | Did Not Report
• DaQuan Jones (DT) | Questionable | Calf | Week 17
• Shaq Thompson (OLB) | Questionable | Neck | Week 17
• Jordan Phillips (DT) | Questionable | Ankle | Week 17
• Curtis Samuel (WR) | Out | Elbow/Knee
• Josh Allen (QB) | Questionable | Foot | Week 17
• Ed Oliver (DT) | Out | Bicep
• Taylor Rapp (S) | Out | Knee
• Damar Hamlin (S) | Out | Pectoral
• Tyler Bass (K) | Out | Left Hip/Groin
• Michael Hoecht (DE) | Out | Achilles
• Landon Jackson (DE) | Out | Knee
• DeWayne Carter (DT) | Out | Achilles
• Dorian Strong (CB) | Out | Neck
• Chase Lundt (OT) | Out | Knee
• Wande Owens (S) | Out | Undisclosed

Bills Stats

The Buffalo Bills have shown a balanced offense with strong performances in both passing and rushing. Josh Allen has been a key player, ranking first in the team for passing touchdowns and fantasy points. James Cook leads in rushing yards and touchdowns, highlighting his importance to the team's ground game. The Bills' defense has been effective, with top rankings in fumbles recovered and passing interceptions. This balanced approach has contributed to their successful season so far.

Bet on the Bills at Caesars.

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